Age - Dependent Change of Serum 5 ƒ ¿ - Dihydrotestosterone and its Relation to Testosterone in Man HAJIME NAWATA

(60-79 years and 80-89 years) men, the mean•}SEM for serum DHT were 98•}12, 91•}9, 82•}7 and 54•}15 (ng/100 ml), respectively. The corresponding values for T were 696•}27, 698•}18, 624•}20 and 457•}21 (ng/100ml). DHT and T showed significant correlation in each age group: r=0.625, p <0.05 (young men), r=0.727, p<0.02 (middle aged men), r=0.673, p <0.05 and r=0.734, p <0.02 (old men), respectively. There was a significant decline in DHT and T levels of 80to 89-year-age group compared those of 30-to 39-year-age group (p<0.05 and p<0.005 respectively). But there was no significant changes in DHT and T levels between other age groups. After 3 daily im injections of 4,000 IU human chorionic gonadotropin (hCG) the levels of serum DHT of the young group (20-32 years) and old group (72-78 years) increased 2.6 times and 1.9 times more, respectively. T increased 2.7 times and 1.4 times more, respectively.